نتایج جستجو برای: روش tvx

تعداد نتایج: 369591  

2014
Kyle L. Poulsen Jesus Olivero-Verbel Kevin M. Beggs Patricia E. Ganey Robert A. Roth

Trovafloxacin (TVX) is a drug that has caused idiosyncratic, druginduced liver injury (IDILI) in humans. In a murine model of IDILI, otherwise nontoxic doses of TVX and the inflammagen lipopolysaccharide (LPS) interacted to produce pronounced hepatocellular injury. The liver injury depended on a TVX-induced, small but significant prolongation of tumor necrosis factor-a (TNF) appearance in the p...

Journal: :The Journal of pharmacology and experimental therapeutics 2014
Kyle L Poulsen Jesus Olivero-Verbel Kevin M Beggs Patricia E Ganey Robert A Roth

Trovafloxacin (TVX) is a drug that has caused idiosyncratic, drug-induced liver injury (IDILI) in humans. In a murine model of IDILI, otherwise nontoxic doses of TVX and the inflammagen lipopolysaccharide (LPS) interacted to produce pronounced hepatocellular injury. The liver injury depended on a TVX-induced, small but significant prolongation of tumor necrosis factor-α (TNF) appearance in the ...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2009
Patrick J Shaw Amy C Ditewig Jeffrey F Waring Michael J Liguori Eric A Blomme Patricia E Ganey Robert A Roth

The antibiotic trovafloxacin (TVX) has caused severe idiosyncratic hepatotoxicity in people, whereas levofloxacin (LVX) has not. Mice cotreated with TVX and lipopolysaccharide (LPS), but not with LVX and LPS, develop severe hepatocellular necrosis. Mice were treated with TVX and/or LPS, and hepatic gene expression changes were measured before liver injury using gene array. Hepatic gene expressi...

2014
Kyle L. Poulsen Ryan P. Albee Patricia E. Ganey Robert A. Roth

Trovafloxacin (TVX) is a fluoroquinolone antibiotic known to cause idiosyncratic, drug-induced liver injury (IDILI) in humans. The mechanism underlying this toxicity remains unknown. Previously, an animal model of IDILI in mice revealed that TVX synergizes with inflammatory stress from bacterial lipopolysaccharide (LPS) to produce a hepatotoxic interaction. The liver injury required prolongatio...

Journal: :The Journal of pharmacology and experimental therapeutics 2014
Kyle L Poulsen Ryan P Albee Patricia E Ganey Robert A Roth

Trovafloxacin (TVX) is a fluoroquinolone antibiotic known to cause idiosyncratic, drug-induced liver injury (IDILI) in humans. The mechanism underlying this toxicity remains unknown. Previously, an animal model of IDILI in mice revealed that TVX synergizes with inflammatory stress from bacterial lipopolysaccharide (LPS) to produce a hepatotoxic interaction. The liver injury required prolongatio...

Journal: :The Journal of pharmacology and experimental therapeutics 2009
Patrick J Shaw Patricia E Ganey Robert A Roth

The use of trovafloxacin (TVX), a fluoroquinolone antibiotic, was severely restricted because of an association of TVX therapy with idiosyncratic hepatotoxicity in patients. The mechanisms underlying idiosyncratic toxicity are unknown; however, one hypothesis is that an inflammatory stress can render an individual sensitive to the drug. Previously, we reported that treatment of mice with TVX an...

2014
Ellen M. Vollmers Anthony D’Abramo Susan F. Cotmore Peter Tattersall

The orphan parvovirus tumor virus X (TVX) has potent oncolytic activity. Compared to other viruses from the species Rodent protoparvovirus 1, TVX has a 111 nucleotide deletion in its nonstructural (NS) gene, a 24 nucleotide insertion in VP1, and a 93 nucleotide repeat initiating from the C-terminus of the capsid gene.

Journal: :Journal of biomedical optics 2013
Adnan Mahmood Jeffrey E Grice Michael S Roberts Tarl W Prow

Antibiotic levels in livestock are usually evaluated through destructive analysis. Taking advantage of the fluorescent properties of marbofloxacin (MBX) and trovafloxacin (TVX), multiphoton microscopy (MPM) was evaluated as a minimally invasive and nondestructive method to determine the penetration of TVX and MBX into sheep neutrophils. Standard curves were measured with drug-only solutions and...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2007
Patrick J Shaw Marie J Hopfensperger Patricia E Ganey Robert A Roth

Idiosyncratic adverse drug reactions (IADRs) occur in a small subset of patients, are unrelated to the pharmacological action of the drug, and occur without an obvious relationship to dose or duration of drug exposure. The liver is often the target of these reactions. Why they occur is unknown. One possibility is that episodic inflammatory stress interacts with the drug to precipitate a toxic r...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Jeffrey F Waring Michael J Liguori James P Luyendyk Jane F Maddox Patricia E Ganey Robert F Stachlewitz Colin North Eric A G Blomme Robert A Roth

Idiosyncratic drug toxicity refers to toxic reactions occurring in a small subset of patients and usually cannot be predicted during preclinical or early phases of clinical trials. One hypothesis for the pathogenesis of hepatic idiosyncratic drug reactions is that, in certain individuals, underlying inflammation results in sensitization of the liver, such that injury occurs from an agent that t...

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